The Biological Computing Co., a San Francisco, CA-based brain’s intelligence company, has raised $25 million in a Seed funding round led by Primary, and coincided with the opening of TBC’s flagship lab in San Francisco’s Mission Bay to support customer deployment.
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The company plans to use the funds to grow its operations and advance development.
The Biological Computing Co. (formerly Biological Black Box) is reshaping computing for the post-silicon AI era. TBC links living neurons with modern AI to build more stable, scalable, and efficient models. Its neural-based solution works directly with foundation models to boost performance and reduce compute costs, reflecting the idea that future high-performance computing will increasingly rely on real biology.
“Silicon has taken AI far, but the next big breakthroughs will come from new architectures like biological computing,” said Brian Schechter and Gaby Lorenzi of Primary Ventures. “We believe Alex, Jon, and the TBC team can deliver major improvements for demanding tasks like computer vision and world models, and their early progress shows a new type of AI infrastructure is possible.”
TBC was founded at the crossroads of three global trends: advances in neuroscience, the limits of today’s AI systems, and the growing climate and energy crisis. Current AI architectures rely on brute-force scaling and repeated optimization, which are becoming costly and hard to maintain as systems move beyond static training. This highlights the need for new computing approaches that focus on efficiency, stability, and reliability.
TBC’s neuroscience and engineering team converts real-world data into living neurons, then translates neural activity into enhanced representations that connect with advanced AI models via modular adapters. At the same time, TBC’s Algorithm Discovery platform uses principles from biology to guide the design of new AI systems beyond transformers, creating a compute layer that improves existing architectures rather than replacing them.
“Having worked in both neuroscience and AI, what excites me about TBC is that they aren’t just using metaphors—they’re using living neurons to uncover learning rules for the next generation of AI,” said Tim Gardner, co-founder of Neuralink.
Believing that better computers require a computing revolution, TBC co-founders Alex Ksendsovsky, MD, PhD, and Jon Pomeraniec, MD, MBA, both neurosurgeon-neuroscientists, are creating a new computing approach in which biological networks work alongside silicon. This boosts performance and efficiency in modern AI systems, delivering scalable improvements that are essential for real-world products with strict energy constraints.
“Using the real brain for computing is both the hardest and most obvious idea in computer science,” says Ksendsovsky. “We’re at the start of a major shift, beyond language models and silicon,” added Pomeraniec. “We’re building infrastructure to understand and interact with the world in a completely new way.”
About The Biological Computing Co.
The Biological Computing Co., based in San Francisco, is using biological intelligence to transform computing. Its platform combines living neurons with advanced AI, creating models that are more stable, scalable, and highly efficient for tasks like AI processing and real-time adaptive learning. Founded by neurosurgeon-scientists, biologists, and engineers with expertise in neuroscience, machine learning, computer vision, and AI, TBC is building the future of biocomputing.
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