SUMMARY
- Abcuro raised $66M in Series D funding.
- The funding will support clinical development.
- Abcuro develops treatments for rare autoimmune diseases.
Abcuro, a Newton, MA-based clinical-stage biotechnology company developing therapies for the treatment of autoimmune diseases through precise modulation of cytotoxic T cells, has raised $66 million in a Series D funding round led by New Leaf Venture Partners.
The round also saw participation from abrdn Inc., Bain Capital Life Sciences, Samsara BioCapital, Redmile Group, Mass General Brigham Ventures, RA Capital Management, Pontifax, Sanofi Ventures, Foresite Capital, NEA, Eurofarma Ventures, Kaitai Capital, Soleus Capital, Nancy Chang, Shang Bay, and Rock Springs Capital.
The company will use the funding to advance clinical development of ulviprubart, an investigational monoclonal antibody targeting KLRG1 for patients with less severe Inclusion Body Myositis (IBM).
Funding Snapshot
| Metric | Details |
|---|---|
| Fundraise Amount | $66 Million |
| Funding Stage | Series D |
| Lead Investor | New Leaf Venture Partners |
| Company | Abcuro |
| Sector | Biotechnology / Immunotherapy |
| Headquarters | Newton, Massachusetts, US |
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About Abcuro
Founded as a clinical-stage biotechnology company, Abcuro develops targeted immunotherapies for debilitating and progressive rare autoimmune diseases.
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The company's approach focuses on precisely modulating cytotoxic T cells, which can play a role in driving autoimmune disease. Its lead program, ulviprubart, is designed to target killer cell lectin like receptor G1 (KLRG1).
Core offerings include:
- Targeted immunotherapies
- Cytotoxic T-cell modulation
- Ulviprubart clinical development
- Treatments for rare autoimmune diseases
Core Technologies / Products / Services
| Capability/Product | Application/Use Case |
| Ulviprubart | Investigational therapy for Inclusion Body Myositis |
| KLRG1 Targeting | Designed to modulate pathogenic cytotoxic T cells |
| Cytotoxic T-Cell Modulation | Targets immune cells involved in autoimmune disease |
Leadership Comments
“We are pleased to have this opportunity to further evaluate ulviprubart in patients with IBM, a devastating progressive disease,” said Alex Martin, Chief Executive Officer of Abcuro.
“The MUSCLE study provided encouraging data in a pre-defined analysis of patients with less severe disease, underscoring ulviprubart’s unique mechanism of targeting highly differentiated cytotoxic T cells expressing KLRG1,” said Namita Goyal, MD, Chief of the Neuromuscular Division at the University of California, Irvine School of Medicine.







