
Almanac Health, a Boston, MA-based provider of a research-validated clinical AI platform and an evidence-based clinical decision support company, has raised $10 million in a Seed funding round led by F-Prime, with participation from General Catalyst (which previously led the company’s Pre-Seed round with participation from Soma Capital) and Lightspeed Venture Partners. The raise brought the total amount to nearly $12M.
The company plans to use the funds to expand its team in clinical medicine, AI research, and health systems infrastructure.
Almanac Health is a clinical AI platform that gives doctors specialist-level support at the point of care. It works within existing EHR systems, adheres to institutional controls, and is supported by peer-reviewed evidence. The platform is currently being tested in academic medical centers.
The company plans to use the funds to expand its team in clinical medicine, AI research and health systems infrastructure, while also advancing R&D with a focus on privacy, reliability and thorough evaluation before deployment.
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Cyril Zakka, MD, has worked at the intersection of medicine and AI across clinical practice, research, and industry. After earning his medical degree, he conducted machine learning research at Stanford, where he built one of the first retrieval-augmented AI systems for clinical use. This approach grounds AI in trusted medical knowledge and is now widely used. His work was published in NEJM AI and became one of the journal’s most cited papers. He later led health AI at Hugging Face before founding Almanac Health.
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“We believe the next generation of healthcare infrastructure will be defined by how effectively it translates frontier intelligence into everyday clinical decisions. Almanac is doing exactly that, building a physician centric platform that brings trusted, evidence based intelligence into the workflow, with the alignment and accountability required for true health assurance,” said Alexandre Momeni, Partner at General Catalyst.
“Cyril is one of the rare founders who has both the clinical training and the technical depth to build AI that clinicians will actually trust, as well as the discipline to validate it before deploying it. Almanac Health represents what we believe the next generation of healthcare AI should look like: grounded in research, governed by institutions, and built with incentives that put clinicians and patients first,” said Carl Byers, Partner at F-Prime.
“There is no shortage of technologies promising to transform medicine. But few are grounded in real evidence, built with integrity, and deserving of the trust of the people and organizations that use them. Almanac Health’s goal is to build clinical AI that meets that standard and is validated through research, with incentives aligned with clinicians and patients. We’re focused on getting that right,” said Cyril Zakka, MD, founder and CEO of Almanac Health.
About Almanac Health
Founded by Cyril Zakka, Almanac Health is a clinical AI platform that provides doctors with specialist level, evidence based decision support at the point of care. It works within existing EHR systems, adheres to institutional controls, and is free of pharmaceutical advertising. The platform is backed by peer reviewed research and supported by investors like F-Prime, General Catalyst and Lightspeed Venture Partners.
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