Cadence Raises $100M in Series C Funding Led by Spark Capital

The round also saw participation from Thrive Capital, General Catalyst, Coatue, B Capital, Corewell Health Ventures, Memorial Hermann, and Duke Health.

The company plans to use the funding to expand into new health systems, improve its AI agents, and grow its work in value-based care models.

Today, Cadence also announced new partnerships with Duke Health, a leading academic health system in North Carolina, and Texas Health Resources, a major nonprofit provider in North Texas.

Cadence now works with more than 20 health systems and supports over 100,000 active patients. The company has shown strong clinical results in peer-reviewed studies and helps save Medicare about $2.7 million each week. In 2025, Cadence also tripled its annual recurring revenue.

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Cadence’s Clinical Intelligence helps identify risk early and take action between visits, keeping older adults healthier while allowing clinicians to focus on the most important care.

The platform is integrated into health systems, electronic medical records, and clinical workflows. AI agents monitor patient vitals daily, support medication adjustments, and provide personalized lifestyle coaching.

Chronic disease is the biggest driver of healthcare costs in the U.S., and much of it is preventable. Cadence is building AI to extend the clinical workforce and reduce costs from unmanaged chronic conditions. The goal is to improve care quality while helping lower the overall cost of healthcare.

By keeping patients engaged between visits, Cadence builds a real-time data system that helps AI deliver better care. Incoming vital alerts are now addressed in a median of just 3.5 minutes, and 55% are resolved without needing human intervention.

Across real world use, and peer reviewed studies, Cadence has shown strong results, including a 230% increase in heart failure patients on guideline-directed therapy and a 70% improvement in blood pressure control for hypertension patients. The platform has also led to a 27% reduction in hospital admissions and a $1,302 per-patient annual decrease in total care costs. These outcomes are consistent across rural and underserved communities, with the model delivering more than $3 in value to Medicare for every $1 spent.

“We built Cadence to solve the clinical labor constraint at the heart of the chronic disease crisis. Our AI automates care under close supervision, guided by our medical group, governed by our health system clinical protocols, and reimbursed through billing infrastructure and at-risk contracts,” said Chris Altchek, founder and CEO of Cadence. “We're treating 100,000 patients with that system today, alongside partners committed to changing the status quo in chronic care. This investment builds the infrastructure to treat millions.”

“We believe the most consequential AI companies of the next decade will be built in categories where the technology changes the underlying mechanics of the business. Cadence has done the hardest work first – demonstrating clinical outcomes, building trust with the country's leading health systems, and proving out the safe and effective deployment of AI inside care delivery,” said Will Reed, partner at Spark Capital and new Cadence board member. “There is no other AI care platform in the country with this combination of scale, peer-reviewed clinical outcomes, and economic proof.”

“At Duke Health, our mission is to advance the health of our patients and the communities we serve. The moments that matter most for a patient's health often happen at home, not in the clinic,” said Jeffrey Ferranti, MD, MS, Senior Vice President and Chief Digital Officer of Duke Health. “With Cadence, we stay connected to patients with chronic conditions around the clock, monitoring their health continuously so we can intervene early and keep them healthy. Together, we're reimagining what care can be: healthier patients and a stronger, more affordable health system for all.”

About Cadence

Founded in 2020 by Chris Altchek, Cadence is a clinical AI company focused on automating chronic disease care. Its Clinical Intelligence handles routine tasks like patient monitoring, risk detection and care coordination, allowing clinicians to focus on higher level medical decisions. Working with more than 20 leading health systems, Cadence integrates deeply with electronic medical records and operates through a dedicated medical group. With experience supporting over 100,000 patients, the system learns from real world care, and continues to improve as it scales.

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